{"id":234,"date":"2023-08-22T10:36:59","date_gmt":"2023-08-22T08:36:59","guid":{"rendered":"https:\/\/biomat.ch.pw.edu.pl\/?p=234"},"modified":"2024-07-04T22:51:00","modified_gmt":"2024-07-04T20:51:00","slug":"our-work-published-in-bioomacromoelcues","status":"publish","type":"post","link":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/2023\/08\/22\/our-work-published-in-bioomacromoelcues\/","title":{"rendered":"Highly Potent Antibacterial Agents with Activity and Toxicity Modulated by the Polymer Molecular Weight"},"content":{"rendered":"\n<p class=\"has-small-font-size\"><em>by<\/em> <\/p>\n\n\n\n<p>Pachla, J.; Kopiasz, R. J.; Marek, G.; Tomaszewski, W.; G\u0142ogowska, A.; Dr\u0119\u017cek, K.; Kowalczyk, S.; Podg\u00f3rski, R.; Butruk-Raszeja, B.; Ciach, T.; Mierzejewska, J.; Plichta, A.; Augustynowicz-Kope\u0107, E.; Ja\u0144czewski, D.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><a href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.biomac.3c00139\"><img fetchpriority=\"high\" decoding=\"async\" width=\"310\" height=\"166\" src=\"https:\/\/biomat.ch.pw.edu.pl\/wp-content\/uploads\/2024\/06\/Picture1.jpg\" alt=\"\" class=\"wp-image-237 size-full\"\/><\/a><\/figure><div class=\"wp-block-media-text__content\">\n<p><em>Biomacromolecules<\/em> <strong>2023<\/strong>, <em>24<\/em> (5), 2237\u20132249<\/p>\n\n\n\n<p><a href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.biomac.3c00139\">https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.biomac.3c00139<\/a><\/p>\n<\/div><\/div>\n\n\n\n<p>Cationic polymers have been extensively investigated as a<br>potential replacement for traditional antibiotics. Here, we examined the<br>effect of molecular weight (MW) on the antimicrobial, cytotoxic, and<br>hemolytic activity of linear polytrimethylenimine (L-PTMI). The results<br>indicate that the biological activity of the polymer sharply increases as MW<br>increases. Thanks to a different position of the antibacterial activity and<br>toxicity thresholds, tuning the MW of PTMI allows one to achieve a<br>therapeutic window between antimicrobial activity and toxicity concentrations.<br>L-PTMI presents significantly higher antimicrobial activity against<br>model microorganisms than linear polyethylenimine (L-PEI) when<br>polymers with a similar number of repeating units are compared. For the<br>derivatives of L-PTMI and L-PEI, obtained through N-monomethylation and partial N,N-dimethylation of linear polyamines, the<br>antimicrobial activity and toxicity were both reduced; however, resulting selectivity indices were higher. Selected materials were<br>tested against clinical isolates of pathogens from the ESKAPE group and Mycobacteria, revealing good antibacterial properties of LPTMI<br>against antibiotic-resistant strains of Gram-positive and Gram-negative bacteria but limited antibacterial properties against<br>Mycobacteria.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>by Pachla, J.; Kopiasz, R. J.; Marek, G.; Tomaszewski, W.; G\u0142ogowska, A.; Dr\u0119\u017cek, K.; Kowalczyk, S.; Podg\u00f3rski, R.; Butruk-Raszeja, B.; Ciach, T.; Mierzejewska, J.; Plichta, A.; Augustynowicz-Kope\u0107, E.; Ja\u0144czewski, D. Biomacromolecules 2023, 24 (5), 2237\u20132249 https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.biomac.3c00139 Cationic polymers have been extensively investigated as apotential replacement for traditional antibiotics. Here, we examined theeffect of molecular weight [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":268,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-234","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications"],"_links":{"self":[{"href":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/posts\/234","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/comments?post=234"}],"version-history":[{"count":11,"href":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/posts\/234\/revisions"}],"predecessor-version":[{"id":305,"href":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/posts\/234\/revisions\/305"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/media\/268"}],"wp:attachment":[{"href":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/media?parent=234"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/categories?post=234"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/tags?post=234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}