{"id":402,"date":"2024-11-08T14:31:22","date_gmt":"2024-11-08T13:31:22","guid":{"rendered":"https:\/\/biomat.ch.pw.edu.pl\/?p=402"},"modified":"2024-12-09T15:32:52","modified_gmt":"2024-12-09T14:32:52","slug":"biomacromolecules_2024","status":"publish","type":"post","link":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/2024\/11\/08\/biomacromolecules_2024\/","title":{"rendered":"Antimicrobial Macrocycles \u2013 Synthesis, Characterization and Activity Comparison with their Linear Polycationic Analogues"},"content":{"rendered":"\n<p class=\"has-small-font-size\"><em>by<\/em> <\/p>\n\n\n\n<p class=\"has-medium-font-size\">Kopiasz, R. J.*;&nbsp; Dranka, M.; Tomaszewski, W.; Kowalska, P.; Butruk-Raszeja, B.; Dr\u0119\u017cek, K.; Mierzejewska, J.; Ciach, T.; Ja\u0144czewski, D.*<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity is-style-default\"\/>\n\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\">\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1440\" height=\"672\" src=\"https:\/\/biomat.ch.pw.edu.pl\/wp-content\/uploads\/2024\/10\/TOC.jpg\" alt=\"\" class=\"wp-image-404\"\/><\/figure>\n\n\n\n<p>Biomacromolecles <strong>2024<\/strong>, <em>25<\/em> (12), 7814\u20137827.<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1021\/acs.biomac.4c01099\" data-type=\"link\" data-id=\"https:\/\/doi.org\/10.1021\/acs.biomac.4c01099\">https:\/\/doi.org\/10.1021\/acs.biomac.4c01099<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n<p id=\"sp0025\">One of the promising candidates for new antimicrobial agents are membrane-lytic compounds killing microbes through cell membrane permeabilization, such as antimicrobial peptides (AMPs) and their synthetic mimics (SMAMPs). Although SMAMPs have been under investigation for nearly 30 years, a few challenges must be addressed before they can reach clinical use. In this work, a step-growth polymerization leading to already known highly antimicrobial ionenes was redirected toward the formation of macrocyclic quaternary ammonium salts (MQAs) employing high dilution principle. Antimicrobial assays and cytotoxicity studies revealed high antimicrobial activity of MQAs, and&nbsp; better selectivity than their polymeric analogues. Therefore, MQAs seem to be a new class of promising antibacterial agents. Additionally, membrane lytic experiments using large unilamellar liposomes (LUVs) and whole cells revealed significant differences between MQAs and ionenes in their ability to adsorb onto the surface of LUVs and microbes, as well as their ability to&nbsp; permeate the lipid bilayer.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>by Kopiasz, R. J.*;&nbsp; Dranka, M.; Tomaszewski, W.; Kowalska, P.; Butruk-Raszeja, B.; Dr\u0119\u017cek, K.; Mierzejewska, J.; Ciach, T.; Ja\u0144czewski, D.* Biomacromolecles 2024, 25 (12), 7814\u20137827. https:\/\/doi.org\/10.1021\/acs.biomac.4c01099 One of the promising candidates for new antimicrobial agents are membrane-lytic compounds killing microbes through cell membrane permeabilization, such as antimicrobial peptides (AMPs) and their synthetic mimics (SMAMPs). Although [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":584,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-402","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications"],"_links":{"self":[{"href":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/posts\/402","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/comments?post=402"}],"version-history":[{"count":6,"href":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/posts\/402\/revisions"}],"predecessor-version":[{"id":583,"href":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/posts\/402\/revisions\/583"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/media\/584"}],"wp:attachment":[{"href":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/media?parent=402"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/categories?post=402"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biomat.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/tags?post=402"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}