BioMatWUT group
Led by Professor Dominik Jańczewski, the BioMatWUT research group focuses on explointing polymeric materials for bio-applications, particularly targeting the critical issue of antibiotic resistance. With antibiotic-resistant bacteria posing a significant global health threat, our research addresses this by developing advanced polymers with antimicrobial properties. Antibiotic-resistant infections, including those caused by methicillin-resistant Staphylococcus aureus (MRSA), result in approximately 100,000 deaths annually in the United States alone, with 20,000 attributed to MRSA infections.1
Research Areas and Approaches
Our work centers on the synthesis and in-depth study of novel polymeric materials, correlating polymer molecular structures with their biological activity to create effective antimicrobial solutions and understand toxicity mechanisms. Through a variety of polymerization techniques and use of post-polymerization modification (PPM) methods,2 we tailor molecular structures to achieve targeted biological responses.
An important aspect of our research is evaluating polymer toxicity, particularly in solution, to guide the design of safer antibacterial agents and minimize potential human and environmental impacts. Additionally, we study the activity and toxicity of polymers embedded within polymeric matrices, such as foils and coatings, extending our materials’ practical applications.
Our team employs a range of biochemical and microbiological techniques,3 working with model organisms and, through collaborations, testing against pathogenic strains to gain insights into polymer efficacy and safety.
Current Focus
Recently, our research has concentrated on two promising classes of polymers: (i) secondary polyamines4 and (ii) polycationic ionenes.5 These classes feature highly active molecules, including oligomeric and macrocyclic structures, offering significant potential for antimicrobial applications.
To learn more about our research or explore collaboration opportunities, please feel free to contact us directly.
