BioMat WUT
polymers and materials for bioapplications
Latest news
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Highly Potent Antibacterial Agents with Activity and Toxicity Modulated by the Polymer Molecular Weight
by Pachla, J.; Kopiasz, R. J.; Marek, G.; Tomaszewski, W.; Głogowska, A.; Drężek, K.; Kowalczyk, S.; Podgórski, R.; Butruk-Raszeja, B.; Ciach, T.; Mierzejewska, J.; Plichta, A.; Augustynowicz-Kopeć, E.; Jańczewski, D. Biomacromolecules 2023, 24 (5), 2237–2249 https://pubs.acs.org/doi/full/10.1021/acs.biomac.3c00139 Cationic polymers have been extensively investigated as apotential replacement for traditional antibiotics. Here, we examined theeffect of molecular weight…
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Main-Chain Flexibility and Hydrophobicity of Ionenes Strongly Impact Their Antimicrobial Activity: An Extended Study on Drug Resistance Strains and Mycobacterium.
by Kopiasz, R. J.; Zabost, A.; Myszka, M.; Kuźmińska, A.; Drężek, K.; Mierzejewska, J.; Tomaszewski, W.; Iwańska, A.; Augustynowicz-Kopeć, E.; Ciach, T.; Jańczewski, D. RSC Adv. 2022, 12 (40), 26220–26232 https://doi.org/10.1039/D2RA04121A The spread of antibiotic-resistant pathogens and the resurgence of tuberculosis disease are major motivations to search for novel antimicrobial agents. Some promising candidates in…
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Influence of PEG Subunit on the Biological Activity of Ionenes: Synthesis of Novel Polycations, Antimicrobial and Toxicity Studies
by Kopiasz, R. J.; Kulbacka, N.; Drężek, K.; Podgórski, R.; Łojszczyk, I.; Mierzejewska, J.; Ciach, T.; Augustynowicz‐Kopeć, E.; Głogowska, A.; Iwańska, A.; Tomaszewski, W.; Jańczewski, D. Macromol. Biosci. 2022, 22 (7), 2200094. https://onlinelibrary.wiley.com/doi/10.1002/mabi.202200094 An alarming increase of antibiotic resistance among pathogens creates an urgent need to develop new antimicrobial agents. Many reported polycations show high…
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Controlled post-polymerization modification method and its application for construction of macromolecular membrane-lytic agents
The post-polymerization modification (PPM) is an approach to change the structure of a polymer at the final stage of synthesis when the polymerization process is already completed. Project funded under the OPUS scheme by National Science Center, Poland.
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Amphiphilic polymers for the controlled disruption of the cell membrane: stimuli responsive action, activity against Mycobacterium
This project aims to research the mechanisms by which specific antimicrobial amphiphilic polymers interact with cell membranes, with a focus on redox responsive polymers disrupting lipid bilayer. Project founded under the SONATA-Bis scheme by National Science Center, Poland.