Category: publications
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Phospholipid composition changes in bacterial membranes: A molecular mechanism of antibiotic resistance
A review paper from a collaborative project between our group and the group of Prof. K. Pawlak has just been published in Advances in Colloid and Interface Science, and it examines changes in the bacterial lipid bilayer related to antibiotic resistance.
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Ferrocene-Grafted Polyethyleneimines, Stimuli Responsive Macromolecules with Antimicrobial Properties
by Eryk Grzechnik, Jolanta Mierzejewska, Karolina Drężek, Waldemar Tomaszewski, Łukasz Górski, Dominik Jańczewski* Macromolecular Chemistry and Physics 2025, https://doi.org/10.1002/macp.202500219 The widespread resistance of pathogenic bacteria to current antimicrobial drugs poses a serious challenge to modern civilization and stimulates the search for novel antibacterial agents. In this work, we investigated a series of stimuli-responsive polymers with…
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Antimicrobial Macrocycles – Synthesis, Characterization and Activity Comparison with their Linear Polycationic Analogues
by Kopiasz, R. J.*; Dranka, M.; Tomaszewski, W.; Kowalska, P.; Butruk-Raszeja, B.; Drężek, K.; Mierzejewska, J.; Ciach, T.; Jańczewski, D.* Biomacromolecles 2024, 25 (12), 7814–7827. https://doi.org/10.1021/acs.biomac.4c01099 One of the promising candidates for new antimicrobial agents are membrane-lytic compounds killing microbes through cell membrane permeabilization, such as antimicrobial peptides (AMPs) and their synthetic mimics (SMAMPs). Although…
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Lactide oligomers modified with linear polyethyleneimine for antibacterial coatings
by Iuliano, A.*; Kukuć, M.; Pachla, J.; Jańczewski, D.; Mierzejewska J.; Drężek, K. Polym.Chem. 2024 https://doi.org/10.1039/d4py00605d Lactide oligomers were synthesized in the presence of glycidol via ring opening solution polymerization and used in the addition reaction with linear polyethyleneimine (L-PEI). Detailed analysis of the lactide oligomerswas conducted using 1H NMR, GPC and MALDI-ToF. L-PEI with…
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Unlocking the Potential: PEGylation and Molecular Weight Reduction of Ionenes for Enhanced Antifungal Activity and Biocompatibility
by Kurzyna, J. M.; Kopiasz, R. J.; Paul, M.; Flont, M.; Baranowska, P.; Mierzejewska, J.; Drężek, K.; Tomaszewski, W.; Jastrzębska, E.; Jańczewski, D. Macromol. Biosci. 2024, 24(9) 2400032. https://doi.org/10.1002/mabi.202400032 Numerous synthetic polymers, imitating natural antimicrobial peptides, have demonstrated potent antimicrobial activity, positioning them as potential candidates for new antimicrobial drugs. However, the high activity of these…
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L-PTMI-Co-L-PEI Copolymers Obtained through Copolymerization of Cyclic Imino Ethers and Their Chain Modification: Antibacterial Properties and Cytotoxicity
by Pachla, J.; Kowalczyk, S.; Tomaszewski, W.; Gnyszka, A.; Flont, M.; Grzechnik, E.; Drężek, K.; Plichta, A.; Mierzejewska, J.; Jastrzębska, E.; Jańczewski, D. Eur. Polym. J. 2024, 213, 113088. https://doi.org/10.1016/j.eurpolymj.2024.113088 Polymeric antimicrobial agents are intensively investigated as potential novel antibiotics. In this work we use copolymerization of 2-propyl-2-oxazine (PrOzi) and 2-methyl-2-oxazoline (MeOx) combined with hydrolysis…
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Membrane Lytic Activity of Antibacterial Ionenes, Critical Role of Phosphatidylcholine (PC) and Cardiolipin (CL)
by Kozon-Markiewicz, D.; Kopiasz, R. J.; Głusiec, M.; Łukasiak, A.; Bednarczyk, P.; Jańczewski, D. Colloids Surf. B Biointerfaces 2023, 229, 113480. https://doi.org/10.1016/j.colsurfb.2023.113480 Understanding the mechanism by which an antibacterial agent interacts with a model membrane provides vital information for better design of future antibiotics. In this study, we investigated two antibacterial polymers, hydrophilic C0-T-p and…
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Highly Potent Antibacterial Agents with Activity and Toxicity Modulated by the Polymer Molecular Weight
by Pachla, J.; Kopiasz, R. J.; Marek, G.; Tomaszewski, W.; Głogowska, A.; Drężek, K.; Kowalczyk, S.; Podgórski, R.; Butruk-Raszeja, B.; Ciach, T.; Mierzejewska, J.; Plichta, A.; Augustynowicz-Kopeć, E.; Jańczewski, D. Biomacromolecules 2023, 24 (5), 2237–2249 https://pubs.acs.org/doi/full/10.1021/acs.biomac.3c00139 Cationic polymers have been extensively investigated as apotential replacement for traditional antibiotics. Here, we examined theeffect of molecular weight…
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Main-Chain Flexibility and Hydrophobicity of Ionenes Strongly Impact Their Antimicrobial Activity: An Extended Study on Drug Resistance Strains and Mycobacterium.
by Kopiasz, R. J.; Zabost, A.; Myszka, M.; Kuźmińska, A.; Drężek, K.; Mierzejewska, J.; Tomaszewski, W.; Iwańska, A.; Augustynowicz-Kopeć, E.; Ciach, T.; Jańczewski, D. RSC Adv. 2022, 12 (40), 26220–26232 https://doi.org/10.1039/D2RA04121A The spread of antibiotic-resistant pathogens and the resurgence of tuberculosis disease are major motivations to search for novel antimicrobial agents. Some promising candidates in…
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Influence of PEG Subunit on the Biological Activity of Ionenes: Synthesis of Novel Polycations, Antimicrobial and Toxicity Studies
by Kopiasz, R. J.; Kulbacka, N.; Drężek, K.; Podgórski, R.; Łojszczyk, I.; Mierzejewska, J.; Ciach, T.; Augustynowicz‐Kopeć, E.; Głogowska, A.; Iwańska, A.; Tomaszewski, W.; Jańczewski, D. Macromol. Biosci. 2022, 22 (7), 2200094. https://onlinelibrary.wiley.com/doi/10.1002/mabi.202200094 An alarming increase of antibiotic resistance among pathogens creates an urgent need to develop new antimicrobial agents. Many reported polycations show high…