BioMat WUT
polymers and materials for bioapplications
Latest news
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PhD scholarship available – deadline extended to 15 of August 2024
!!Important update!!, application deadline is extened to 15 August 2024 **Call for Applications for a Doctoral Scholarship in a project founded by National Science Centre Poland** **Controlled Post-Polymerization Modification Method and Its Application in Producing Polymer Agents That Disrupt Cell Wall Structure (ConPPM)** Chemical modification of polymers after the polymerization stage (post-polymerization modification, PPM) is…
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Unlocking the Potential: PEGylation and Molecular Weight Reduction of Ionenes for Enhanced Antifungal Activity and Biocompatibility
by Kurzyna, J. M.; Kopiasz, R. J.; Paul, M.; Flont, M.; Baranowska, P.; Mierzejewska, J.; Drężek, K.; Tomaszewski, W.; Jastrzębska, E.; Jańczewski, D. Macromol. Biosci. 2024, 2400032. https://doi.org/10.1002/mabi.202400032 Numerous synthetic polymers, imitating natural antimicrobial peptides, have demonstrated potent antimicrobial activity, positioning them as potential candidates for new antimicrobial drugs. However, the high activity of these molecules…
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L-PTMI-Co-L-PEI Copolymers Obtained through Copolymerization of Cyclic Imino Ethers and Their Chain Modification: Antibacterial Properties and Cytotoxicity
by Pachla, J.; Kowalczyk, S.; Tomaszewski, W.; Gnyszka, A.; Flont, M.; Grzechnik, E.; Drężek, K.; Plichta, A.; Mierzejewska, J.; Jastrzębska, E.; Jańczewski, D. Eur. Polym. J. 2024, 213, 113088. https://doi.org/10.1016/j.eurpolymj.2024.113088 Polymeric antimicrobial agents are intensively investigated as potential novel antibiotics. In this work we use copolymerization of 2-propyl-2-oxazine (PrOzi) and 2-methyl-2-oxazoline (MeOx) combined with hydrolysis…
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Membrane Lytic Activity of Antibacterial Ionenes, Critical Role of Phosphatidylcholine (PC) and Cardiolipin (CL)
by Kozon-Markiewicz, D.; Kopiasz, R. J.; Głusiec, M.; Łukasiak, A.; Bednarczyk, P.; Jańczewski, D. Colloids Surf. B Biointerfaces 2023, 229, 113480. https://doi.org/10.1016/j.colsurfb.2023.113480 Understanding the mechanism by which an antibacterial agent interacts with a model membrane provides vital information for better design of future antibiotics. In this study, we investigated two antibacterial polymers, hydrophilic C0-T-p and…
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Highly Potent Antibacterial Agents with Activity and Toxicity Modulated by the Polymer Molecular Weight
by Pachla, J.; Kopiasz, R. J.; Marek, G.; Tomaszewski, W.; Głogowska, A.; Drężek, K.; Kowalczyk, S.; Podgórski, R.; Butruk-Raszeja, B.; Ciach, T.; Mierzejewska, J.; Plichta, A.; Augustynowicz-Kopeć, E.; Jańczewski, D. Biomacromolecules 2023, 24 (5), 2237–2249 https://pubs.acs.org/doi/full/10.1021/acs.biomac.3c00139 Cationic polymers have been extensively investigated as apotential replacement for traditional antibiotics. Here, we examined theeffect of molecular weight…
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Main-Chain Flexibility and Hydrophobicity of Ionenes Strongly Impact Their Antimicrobial Activity: An Extended Study on Drug Resistance Strains and Mycobacterium.
by Kopiasz, R. J.; Zabost, A.; Myszka, M.; Kuźmińska, A.; Drężek, K.; Mierzejewska, J.; Tomaszewski, W.; Iwańska, A.; Augustynowicz-Kopeć, E.; Ciach, T.; Jańczewski, D. RSC Adv. 2022, 12 (40), 26220–26232 https://doi.org/10.1039/D2RA04121A The spread of antibiotic-resistant pathogens and the resurgence of tuberculosis disease are major motivations to search for novel antimicrobial agents. Some promising candidates in…
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Influence of PEG Subunit on the Biological Activity of Ionenes: Synthesis of Novel Polycations, Antimicrobial and Toxicity Studies
by Kopiasz, R. J.; Kulbacka, N.; Drężek, K.; Podgórski, R.; Łojszczyk, I.; Mierzejewska, J.; Ciach, T.; Augustynowicz‐Kopeć, E.; Głogowska, A.; Iwańska, A.; Tomaszewski, W.; Jańczewski, D. Macromol. Biosci. 2022, 22 (7), 2200094. https://onlinelibrary.wiley.com/doi/10.1002/mabi.202200094 An alarming increase of antibiotic resistance among pathogens creates an urgent need to develop new antimicrobial agents. Many reported polycations show high…