Category

publikacje 2021

Nasze publikacje z 2021 roku

Influence of lipid bilayer composition on the activity of antimicrobial quaternary ammonium ionenes, the interplay of intrinsic lipid curvature and polymer hydrophobicity, the role of cardiolipin

By D Janczewski, osiagniecia, publikacje 2021

W czasopiśmie Colloids and Surfaces B (vol 207,  112016) ukazała się nasza nowa publikacja: „Influence of lipid bilayer composition on the activity of antimicrobial quaternary ammonium ionenes, the interplay of intrinsic lipid curvature and polymer hydrophobicity, the role of cardiolipin.”

by: Rafał J. Kopiasz, Alicja Rukasz, Karolina Chreptowicz, Rafał Podgórski, Aleksandra Kuźmińska, Jolanta Mierzejewska, Waldemar Tomaszewski, Tomasz Ciach, Dominik Jańczewski

Highlights:

• Series of ionenes with substantial bioactivity against model microorganisms.

• An unusual drop of activity following increase of polymer hydrophobicity.

• Vesicles containing cardiolipin are sensitive toward more hydrophilic ionenes.

• For certain vesicles and concentrations hydrophobic ionenes can reduce release of a dye.

Controlled post-polymerization modification through modulation of repeating unit reactivity: Proof of concept discussed using linear polyethylenimine example

By D Janczewski, osiagniecia, publikacje 2021

Nasza nowa publikacja ukazała się właśnie w czasopiśmie Polymer

Highlights

• Controlled post-polymerization modification method leading to well-defined product

• Reactivity modulation of polymer repeating units

• The influence of field effect on PEI alkylation process

• Numerical simulation of controlled post-polymerization modification

Regulation of Lipid Bilayer Ion Permeability by Antibacterial Polymethyloxazoline‐Polyethyleneimine Copolymers

By publikacje 2021

Ukazała się nasza nowa publikacja w ChemBioChem DOI: 10.1002/cbic.202000656

Dominika Kozon, Piotr Bednarczyk, Adam Szewczyk, Dominik Jańczewski

Regulation of Lipid Bilayer Ion Permeability by Antibacterial Polymethyloxazoline‐Polyethyleneimine Copolymers

The black lipid membrane technique was used to investigate the membrane‐permeabilization abilities of a series of amphiphilic antimicrobial polymers. The most potent antibacterial polymer induces step‐like current behavior typical for an ion‐channel.